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The study participants were randomized into one of nine treatment groups: medical management and placebo; medical management and acamprosate; medical management and naltrexone; medical management and acamprosate and naltrexone; medical management, specialized therapy and placebo; medical management, specialized therapy and acamprosate; medical management, specialized therapy and naltrexone; medical management; specialized therapy and naltrexone and acamprosate; or specialized therapy alone.

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Roughly onethird of those with the disease relapse, or develop treatment resistant tumors, the researchers said.

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