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Green BD, Irwin N, Duffy NA, Gault VA, O'harte FP, Flatt PR 2006 Inhibition of dipeptidyl peptidase-IV activity by metformin enhances the antidiabetic effects of glucagon-like peptide-1.
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This medication stimulates the secretion of hormones such as glucagons-like-peptide and glucose dependent insulinotrophic peptide.
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Other DPP-4 drugs being studied include vildagliptin (Galvus) and saxagliptin.
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In April of 2016 After another year of dallying around, during which unknown numbers of patients were probably injured by this drug and a new one in the same class, Nesina, the FDA issued a safety alert stating, An FDA safety review has found that type 2 diabetes medicines containing saxagliptin and alogliptin may increase the risk of heart failure, particularly in patients who already have heart or kidney disease.
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Pooled data from four trials in a broader type 2 diabetes population (about 40 to 65 years old) confirmed previous findings that there was no overall weight gain in those using once-daily Galvus monotherapy(7).
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Emerging therapies may offer effective and well-tolerated treatment alternatives for elderly patients with T2DM.
AP has had specified relationships on other matters with Novartis, which might have an interest in the submitted work.
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In order to explain the effectiveness of Galvus and to try and provide unbiased information we will look at studies conducted before Galvus came on the market.
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