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Categorical variables were analyzed by the X 2 test and continuous variables were tested with analysis of variance (ANOVA), with treatment used as a factor.

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The results of all laboratory tests were assessed by the investigators for clinical significance and for possible relationship to the study drug.

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In long-term follow-up studies (without placebo control) the effect of Losartan appeared to be maintained for up to a year.

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The primary endpoint of the study was the time to first occurrence of any one of the following events: doubling of serum creatinine, end-stage renal disease (ESRD) (need for dialysis or transplantation), or death.

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